Optical Activity of Nucleic Acid-Thionine Complexes

Optical melting measurements of nucleic acid thermodynamics.

Optical melting experiments provide measurements of thermodynamic parameters for nucleic acids. These thermodynamic parameters are widely used in RNA structure prediction programs and DNA primer design software. This review briefly summarizes the theory and underlying assumptions of the method and provides practical details for instrument calibration, experimental design, and data interpretation.

Complexing properties of nucleic-acid constituents adenine and guanine complexes.

Cobalt, nickel and copper complexes of adenine and guanine, as nucleic-acid constituents, were prepared. The adenine and guanine complexes are of tetrahedral and octahedral geometries, respectively. All are of high spin nature. The nickel complexes are of 2:1 metal:ligand ratio with Ni...Ni direct interaction in the guanine complex. The coordination bonds of adenine metal complexes are calculat...

Analyzing Protein - Nucleic Acid Complexes using Hybrid Methods

The nucleic acid of African Horse-Sickness Virus

Targeted Patterning of Nucleic Acid Probes on Optical Nanostructures

Optically resonant devices are promising as biomolecular sensors due to their ability to concentrate electromagnetic energy into small mode volume, high quality factor nanocavities. We present a parylene patterning technique that enables us to localize the biomolecular interactions of interest to the areas of highest optical intensity in such devices, leading to a device with optimal sensitivit...